In season 3 of True Blood a pack of werewolves were introduced. They were mostly addicted to “V” and were under the command of the Mississippi vampire king, Russel Edgington.
It is not easy tracking down if these are actual wolves or not but in the credits Tim Williams (also from Eight Below and Twilight) and Gayle Phelps (also from Evan Almighty and Dances With Wolves) are listed as animal trainers – both of whom have been known to work with full blooded wolves and high content wolf-hybrids. What little information is out there at this time confirms that they used full blooded wolves and did not use CGI for any of them.
Along with Tim Williams and Gayle Phelps, Elizabeth McMullan, Jeff Lee, Barbara Gaddy-Edrington, David Slldberry, and Shawn Weber were animal trainers on the set. Steve Martin, David Allsberry, Shawn Weber, and Matt Belanger were the animal wranglers. Matt Belanger was also the animal supplier for most of the episodes.