Turner and Hooch
In 1989 Tom Hanks starred in the film “Turner and Hooch” (starred by “Beasley the Dog”) where he is an overly neat (OCD?) police officer who ends up having to take care of a dog who may be a witness to a murder. “Hooch” was a Dogue de Bordeaux (a.k.a . French Mastiff). Of course this set sup the conflict between the overly neat human and his excessively messy and destructive canine companion.
They most likely used the Dogue de Bordeax for many reasons – it’s size, it’s dirty look, as well as its “slobberyness”.
Clint Rowe (also an animal (wolf) trainer for “Men In Black“, “The X-Files“, and “Dr. Dolittle 2“) is credited for being Hooch’s owner and Scott Rowe (who has also done work in “True Lies“, “Cats & Dogs“, “Star Trek Enterprise“, and “Beverly Hills Chihuahua“) was credited as being the animal trainer.